Estudo In Vivo da Biocompatibilidade de Pastas à Base de Iodofórmio em Subcutâneo de Ratos

The endodontic treatment of the teeth with necrotic pulp tries to eliminate the infecting microorganisms of the root canal system and neutralize their toxic products. The delay medication use has been showing to improve the prognostic of the cases associated to periapex lesions. The iodoform has place of prominence among medications due to longevity and regularity of its use. This study has the objective to compare the biocompatibility in vivo of three iodoform base medications. It had been used 15 rats Wistar which had received three dorsal implantations filled with Endoform , Diapex and Iodoform folder in polyethyleneglycol and a fourth empty pipe as control. The animals had been sacrieficed within two, seven and 14 days, the pipes and the adjacent tissue had been histopathological analisis. The results had demonstrate that within two days all materials caused intense inflammatory reaction, however in the Endoform group , necrosis and abscess were still noticed. After seven days the inflamatory response was still the same for the Endoform group, although for the Diapex and iodoform past groups it was already possible to evidence chronic inflammatory infiltrate followed by of angiogenesis and fibrosis. To the 14 days the Diapex" and iodoform folder group had shown intense angiogenesis and fibrosis along with strange body reaction in the areas in contact with the material, while the Endoform group continued showing regions of necrosis and chronic inflammatory infiltrateThe Diapex and the iodoform paste groups seamed o be biocompatible at the intervals of two, seven and 14 days, the same coudn't considered to Endoform group.