Fatty Acid Synthase Inhibition With Orlistat Promotes Apoptosis And Reduces Cell Growth And Lymph Node Metastasis In a Mouse Melanoma Model.

Int J Cancer. 2008 Dec 1;123(11):2557-65. doi: 10.1002/ijc.23835. Carvalho MA, Zecchin KG, Seguin F, Bastos DC, Agostini M, Rangel AL, Veiga SS, Raposo HF, Oliveira HC, Loda M, Coletta RD, Graner E. Abstract Fatty acid synthase (FASN) is the enzyme responsible for the endogenous synthesis of the saturated fatty acid palmitate. In contrast to most normal cells, malignant cells depend on FASN activity for growth and Leia mais